Mesenchymal stem cells in the treatment of osteonecrosis of the jaw
Nifosi Gianfilippo, Nifosi Lorenzo, Nifosi Antonio Fabrizio,
소속 상세정보
( Nifosi Gianfilippo ) - VSHA Fondation Department of Oncology and Hematology
( Nifosi Lorenzo ) - Sante Doree Dental Clinic
( Nifosi Antonio Fabrizio ) - Smart Dental Clinic
Abstract
Medication-related osteonecrosis of the jaw (MRONJ) has recently associated to the increase in antiresorptive and anti-angiogenic drugs prescriptions in the treatment of oncologic and osteoporotic patients. The physiopathogenesis of MRONJ remains unclear and available treatments are unsatisfactory. Newer pharmacological treatments have shown good results, but are not curative and could have major side effects. At the same time as pharmacological treatments, mesenchymal stem cells (MSCs) have emerged as a promising therapeutic modality for tissue regeneration and repair. MSCs are multi-potential non-hematopoietic progenitor cells capable to differentiating into multiple lineages of the mesenchyme. Bone marrow MSCs can differentiate into osteogenic cells and display immunological properties and secrete paracrine anti-inflammatory factors in damaged tissues. The immunomodulatory, reparative, and anti-inflammatory properties of bone marrow MSCs have been tested in a variety of animal models of MRONJ and applied in specific clinical settings. The aim of this review is to discuss critically the immunogenicity and immunomodulatory properties of MSCs, both in vitro and in vivo, the possible underlying mechanisms of their effects, and their potential clinical use as modulators of immune responses in MRONJ, and to identify clinical safety and recommendations for future research.
키워드
Osteonecrosis; Bone regeneration; Mesenchymal stem cell; Cell therapy
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